These buffered local anesthetic solutions were also immediately injected into a clean and dry vial for pH testing. Each sample consisted of 3.8 mL of buffered local anesthetic solution and was tested four separate times at 5-minute intervals. Storage and Stability of Buffered Samples
An earlier study investigated lidocaine stability in aqueous solutions by subjecting lidocaine at various pH, temperature, buffer and metal ion concentrations . The reported mobile phase for HPLC analysis consisted of buffer (0.02 M heptane sulfonic acid and 0.02 M potassium dihydrogen othrophosphate), methanol and tetrahydrofuran (THF). The degradation of lidocaine in aqueous solution obeys the expression k obs = (k H+[H +] + k o ) [H+]/([H + ] + K a + k′o K a([H + ] + K a) where k H+ is the rate constant for hydronium ion catalysis, and k o and k′o are the rate constants for the spontaneous (or water-catalyzed) reactions of protonated and free-base lidocaine. At 80°C, the rate constants for these processes are 1.31 Lidocaine is a synthetic aminoethylamide with local anesthetic and antiarrhythmic properties. Lidocaine stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting the ionic fluxes required for the initiation and conduction of impulses and effecting local anesthesia. Concentrations of buffered lidocaine and epinephrine were performed in order to evaluate their stability. Buffered lidocaine dropped to 66.1% of initial concentrations after 4 weeks when stored at Concentrations of buffered lidocaine and epinephrine were performed in order to evaluate their stability. Buffered lidocaine dropped to 66.1% of initial concentrations after 4 weeks when stored at Although buffered lidocaine has been used in the clinical setting for several years, its long-term physical and chemical stability remains unclear. Larson and others4 examined the stability of buffered lidocaine combined with epinephrine and stored at room temperature (23°C) or under refrigeration (0°C to 4°C), using chromatography to measure
Buffered Lidocaine Hydrochloride Solution With and Without Epinephrine: Stability in Polypropylene Syringes. Can J Hosp Pharm 2009 ; 62, 5: 375-380. 3263 Revue Donnelly R.F. Stability of buffered lidocaine in glass vials. Can J Hosp Pharm 2011 ; 64, 4: 289-290. 3420 Revue El Kateb N, Chaussard M, Bellenger P, Petit A, Faure P.
Objective: To evaluate the safety of buffered lidocaine with and without epinephrine drawn from multiuse vials and stored for up to 4 weeks. Methods: Syringes were filled with lidocaine 1%, lidocaine 1% with 1:100,000 epinephrine, lidocaine 1% with bicarbonate (10:1 ratio), or lidocaine 1% with 1:100,000 epinephrine with bicarbonate (10:1 ratio). An earlier study investigated lidocaine stability in aqueous solutions by subjecting lidocaine at various pH, temperature, buffer and metal ion concentrations . The reported mobile phase for HPLC analysis consisted of buffer (0.02 M heptane sulfonic acid and 0.02 M potassium dihydrogen othrophosphate), methanol and tetrahydrofuran (THF). The degradation of lidocaine in aqueous solution obeys the expression k obs = (k H+[H +] + k o ) [H+]/([H + ] + K a + k′o K a([H + ] + K a) where k H+ is the rate constant for hydronium ion catalysis, and k o and k′o are the rate constants for the spontaneous (or water-catalyzed) reactions of protonated and free-base lidocaine. At 80°C, the rate constants for these processes are 1.31
Buffered lidocaine 1 has a pH level that can minimize the sting or burn associated with standard lidocaine 2. It does however, have a shorter shelf life compared to standard lidocaine and must be compounded by a pharmacy 3. The J-Tip needle-free injector is most frequently used with 1% buffered lidocaine for IV starts.
Buffered lidocaine 1 has a pH level that can minimize the sting or burn associated with standard lidocaine 2. It does however, have a shorter shelf life compared to standard lidocaine and must be compounded by a pharmacy 3. The J-Tip needle-free injector is most frequently used with 1% buffered lidocaine for IV starts.